职称：教授/博士生导师
邮箱：zhaozhenhuan@hbut.edu.cn
研究方向
1) T细胞自身免疫发生机制
2) 免疫干预分子的筛选与鉴定
个人简介
赵震环，bwi437官网教授/博导。2013年前往弗吉尼亚大学任副研究员、研究员，先后参与超过1000万美元的美国国立卫生研究院项目。长期担任Frontier in Cellular & infection Microbiology客座编辑，Journal of the American Society of Nephrology，Frontier in Immunology等期刊审稿人。2024年回国，入选湖北省重点人才计划，湖北省创新团队。
主要从事自身免疫疾病中T细胞的功能与机制研究，特别是狼疮肾炎中自免疫T细胞识别自身抗原和协助自身抗体的功能与机制研究。以第一作者或通讯作者在Annals of the Rheumatic Diseases（2019，2022），Molecular Psychiatry（2025），Clin Immunol，J Biol Chem，Antimicrob Agents Chemothe等期刊发表研究型论文共9篇，累计影响因子103.5，谷歌引用超740次。2019年发表在Annals of the Rheumatic Diseases上的研究型论文‘Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification’被风湿病狼疮领域权威Robert Winchester教授在同期杂志上进行了专题评论，认为该研究推动了学界对狼疮自身免疫反应起源的认识。2025年带队获得生命科学竞赛国家三等奖。
教育经历
2007/09-2012/12，武汉大学，博士
2003/09-2007/06，华中农业大学，学士
工作经历
2024/04-至今：437必赢会员中心，教授
2018/05-2024/04：美国弗吉尼亚大学医学院，免疫、炎症与再生中心，研究员
2013/06-2018/05：美国弗吉尼亚大学医学院，免疫、炎症与再生中心，副研究员
代表性学术论文和专著
1)Wang JL, Ye CH, Teng ZF, Zhou K, Pan LL, Ouyan MD, Zheng Z, Lu M, Li SL, Zhang J, Zheng PC, Zhang J, Zhang H, Lin MH, Zhang LC, Huang SS, Ren XN, Zheng N, Wei WL,Zhao Z#, Wang SB#, Lai ZM#.Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders.Mol Psychiatry. 2025.(自然引索期刊，中科院一区，IF=10.3)
2)Zhao Z, Anderson AN, Kannapell CC, Kwok WW, Gaskin F, Fu SM. HLA-DR3 restricted environmental epitopes from the bacterium Clostridium tetani have T cell cross-reactivity to the SLE-related autoantigen SmD.Front Immunol.2022 Oct 31 (IF=8.7)
3)Zhao Z, Xu B, Wang S, Zhou M, Huang Y, Guo C, Li M, Zhao J, Sung SJ, Gaskin F, Yang N, Fu SM. Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity.Annals of the Rheumatic Diseases. 2022 Jul;81(7):1006-1012. doi: 10.1136/annrheumdis-2021-221985. Epub 2022 Apr 12. PMID: 35414518; PMCID: PMC9262832.(自然引索期刊，中科院一区，IF=20)
4)Zhao Z, Ren J, Dai C, Kannapell C, Wang Q, Gaskin F, Fu SM. Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification.Annals of the Rheumatic Diseases. Published Online First: 25 September 2018.doi:10.1136/annrheumdis-2018-214125.(自然引索期刊，中科院一区，IF=20；该研究被编辑专题评论：Editorials Comment byWinchester R.What structures are seen by a T cell in the immune response to a lupus autoantigen?Annals of the Rheumatic Diseases2019;78:291-292.)
5)Zhao Z, Qiao H, Ge Y, Kannapel CC, Sung SJ, Gaskin F, Tung KSK, Fu SM. Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage.Clin Immunol. 2021 Mar;224:108675. doi: 10.1016/j.clim.2021.108675. Epub 2021 Jan 19. PMID: 33482358.(IF=10.1)
6)Zhao Z, Ren J, Dai C, Kannapell C, Wang Q, Gaskin F, Fu SM. HLA-DR3 Restricted T Cell Response to Smd and Ro60 Reveals Multiple Cross-Reactive Intra- and Inter-Molecular T Cell Epitopes: Unique Antigenic Structures of Lupus-Related Auto-Antigens and the Basis for B Cell Epitope Spreading [abstract].Arthritis Rheumatol.2016; 68 (suppl 10). http://acrabstracts.org/abstract/hla-dr3-restricted-t-cell-response-to-smd-and-ro60-reveals-multiple-cross-reactive-intra-and-inter-molecular-t-cell-epitopes-unique-antigenic-structures-of-lupus-related-auto-antigens-and-the-basis/. Accessed January 20, 2017.
7)Zhao Z, Ren J, Dai C, Kannapell C, Wang Q, Gaskin F, Fu SM. HLA-DR3 Restricted Response to Lupus-Related Auto-Antigen Smd: Autoreactive T Cells Are Inherent in Normal Immune Repertoires [abstract].Arthritis Rheumatol.2016; 68 (suppl 10). http://acrabstracts.org/abstract/hla-dr3-restricted-response-to-lupus-related-auto-antigen-smd-autoreactive-t-cells-are-inherent-in-normal-immune-repertoires/. Accessed January 20, 2017.
8) Fu SM, Dai C,Zhao Z, Gaskin F. Anti-dsDNA Antibodies are one of the many autoantibodies in systemic lupus erythematosus.F1000Res.2015 Oct 1; 4(F1000 Faculty Rev):939. doi 10.12688/f1000research.6875.1. PMCID: PMC4648223.
9) Hong W, Zhang R, Di Z, He Y,Zhao Z, Hu J, Wu Y, Li W, Cao Z. Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.Biomaterials. 2013 Apr;34(13):3511-22. doi: 10.1016/j.biomaterials.2013.01.075. Epub 2013 Feb 13. PubMed PMID: 23415044.en.
10)Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W, Cao Z. Mucroporin-M1inhibits hepatitis B virus replication by activating the mitogen-activatedprotein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.J Biol Chem.2012 Aug 31;287(36):30181-90. doi: 10.1074/jbc.M112.370312. Epub 2012 Jul 12. PubMed PMID: 22791717; PubMed Central PMCID: PMC3436272.
11) Li Q,Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, WuY, Yan H, Li W. Virucidal activity of a scorpion venom peptide variantmucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses.Peptides. 2011 Jul;32(7):1518-25. doi: 10.1016/j.peptides.2011.05.015. Epub 2011 May 19.PubMed PMID: 21620914.
12) Yan R,Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W. A new natural α-helical peptide from the venom of the scorpionHeterometrus petersiikills HCV.Peptides. 2011 Jan;32(1):11-9. doi: 10.1016/j.peptides.2010.10.008.Epub 2010 Oct 13. PubMed PMID: 20950663.
13) Fan S, Sun Z, Jiang D, Dai C, Ma Y,Zhao Z, Liu H, Wu Y, Cao Z, Li W. BmKCT toxin inhibits glioma proliferation and tumor metastasis.Cancer Lett. 2010 May 28;291(2):158-66. doi: 10.1016/j.canlet.2009.10.011. Epub 2009 Nov 10. PubMed PMID: 19906483.
14)Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, Cao Z, Li W. Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates.Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7. doi: 10.1128/AAC.01436-08. Epub 2009 May 18. PubMed PMID: 19451300; PubMed Central PMCID: PMC2715652. (* co-first authors).
15) Dai C, Ma Y,Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z, Li W. Mucroporin, the first cationic host defense peptide from the venom of Lychasmucronatus.Antimicrob Agents Chemother. 2008 Nov;52(11):3967-72. doi: 10.1128/AAC.00542-08. Epub 2008 Sep 8. PubMed PMID: 18779362; PubMed Central PMCID: PMC2573117.
